Gene: TIMELESS

Alternate names for this Gene: TIM|TIM1|hTIM

Gene Summary: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders.

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.3

Description of this Gene: timeless circadian regulator

Type of Gene: protein-coding

rs11171846 in TIMELESS gene and Cytokine Measurement PMID 22610502 2012 Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.

rs2291738 in TIMELESS gene and Ocular axial length PMID 24144296 2013 Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.

rs2638286 in TIMELESS gene and Serum albumin measurement PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.