Gene: TK1

Alternate names for this Gene: TK2

Gene Summary: The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers.

Gene is located in Chromosome: 17

Location in Chromosome : 17q25.3

Description of this Gene: thymidine kinase 1

Type of Gene: protein-coding

Gene: AFMID

Alternate names for this Gene: FKF|KF|KFA

Gene Summary:

Gene is located in Chromosome: 17

Location in Chromosome : 17q25.3

Description of this Gene: arylformamidase

Type of Gene: protein-coding

rs144204502 in TK1;AFMID gene and Finding of Mean Corpuscular Hemoglobin PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs144204502 in TK1;AFMID gene and Mean Corpuscular Volume (result) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs144204502 in TK1;AFMID gene and RDW - Red blood cell distribution width result PMID 28957414 2017 Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs144204502 in TK1;AFMID gene and Red cell distribution width determination PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

PMID 28957414 2017 Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.