Gene: TMEM150B

Alternate names for this Gene: DRAM3|TMEM224|TTN2

Gene Summary: This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants.

Gene is located in Chromosome: 19

Location in Chromosome : 19q13.42

Description of this Gene: transmembrane protein 150B

Type of Gene: protein-coding

rs11668344 in TMEM150B gene and Age at menarche PMID 29773799 2018 Elucidating the genetic architecture of reproductive ageing in the Japanese population.

rs11668344 in TMEM150B gene and Age at menopause PMID 23307926 2013 A genome-wide association study of early menopause and the combined impact of identified variants.

PMID 22267201 2012 Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

PMID 26414677 2015 Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.

PMID 23424626 2013 Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study.

PMID 19448619 2009 Loci at chromosomes 13, 19 and 20 influence age at natural menopause.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs201935337 in TMEM150B gene and Major Depressive Disorder PMID 27777418 2017 The PHF21B gene is associated with major depression and modulates the stress response.