Gene: TMOD2

Alternate names for this Gene: N-TMOD|NTMOD

Gene Summary: This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene is located in Chromosome: 15

Location in Chromosome : 15q21.2

Description of this Gene: tropomodulin 2

Type of Gene: protein-coding

rs17610835 in TMOD2 gene and Intelligence PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.