Gene: TMX1

Alternate names for this Gene: PDIA11|TMX|TXNDC|TXNDC1

Gene Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides.

Gene is located in Chromosome: 14

Location in Chromosome : 14q22.1

Description of this Gene: thioredoxin related transmembrane protein 1

Type of Gene: protein-coding