Gene: TNF
Alternate names for this Gene: DIF|TNF-alpha|TNFA|TNFSF2|TNLG1F
Gene Summary: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Gene is located in Chromosome: 6
Location in Chromosome : 6p21.33
Description of this Gene: tumor necrosis factor
Type of Gene: protein-coding