Gene: TNFRSF10B

Alternate names for this Gene: CD262|DR5|KILLER|KILLER/DR5|TRAIL-R2|TRAILR2|TRICK2|TRICK2A|TRICK2B|TRICKB|ZTNFR9

Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Gene is located in Chromosome: 8

Location in Chromosome : 8p21.3

Description of this Gene: TNF receptor superfamily member 10b

Type of Gene: protein-coding

Gene: LOC286059

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 8

Location in Chromosome : 8p21.3

Description of this Gene: TNF receptor superfamily member 10d pseudogene

Type of Gene: pseudo

rs78905543 in TNFRSF10B;LOC286059 gene and Mean Corpuscular Volume (result) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs11135694 in TNFRSF10B;LOC286059 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.