Gene: TNFRSF18

Alternate names for this Gene: AITR|CD357|ENERGEN|GITR|GITR-D

Gene Summary: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.33

Description of this Gene: TNF receptor superfamily member 18

Type of Gene: protein-coding