Gene: TNFRSF19

Alternate names for this Gene: TAJ|TAJ-alpha|TRADE|TROY

Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene is located in Chromosome: 13

Location in Chromosome : 13q12.12

Description of this Gene: TNF receptor superfamily member 19

Type of Gene: protein-coding

rs3814787 in TNFRSF19 gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs11841272 in TNFRSF19 gene and Bone Density PMID 30690781 2019 Joint Association Analysis Identified 18 New Loci for Bone Mineral Density.

rs9510787 in TNFRSF19 gene and Nasopharyngeal Neoplasms PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

PMID 26545403 2016 A GWAS Meta-analysis and Replication Study Identifies a Novel Locus within CLPTM1L/TERT Associated with Nasopharyngeal Carcinoma in Individuals of Chinese Ancestry.

rs9510787 in TNFRSF19 gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.