Gene: TNFRSF8

Alternate names for this Gene: CD30|D1S166E|Ki-1

Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.22

Description of this Gene: TNF receptor superfamily member 8

Type of Gene: protein-coding