Gene: TNFSF13

Alternate names for this Gene: APRIL|CD256|TALL-2|TALL2|TNLG7B|TRDL-1|UNQ383/PRO715|ZTNF2

Gene Summary: The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Gene is located in Chromosome: 17

Location in Chromosome : 17p13.1

Description of this Gene: TNF superfamily member 13

Type of Gene: protein-coding

Gene: TNFSF12-TNFSF13

Alternate names for this Gene: TWE-PRIL

Gene Summary: This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines.

Gene is located in Chromosome: 17

Location in Chromosome : 17p13.1

Description of this Gene: TNFSF12-TNFSF13 readthrough

Type of Gene: protein-coding

rs3803800 in TNFSF13;TNFSF12-TNFSF13 gene and IGA Glomerulonephritis PMID 22197929 2011 A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.

rs143094271 in TNFSF13;TNFSF12-TNFSF13 gene and Plexiform leiomyoma PMID 30194396 2018 Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.

rs3803800 in TNFSF13;TNFSF12-TNFSF13 gene and Serum albumin measurement PMID 22558069 2012 Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese.

rs143094271 in TNFSF13;TNFSF12-TNFSF13 gene and Uterine Fibroids PMID 30194396 2018 Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.