Gene: TNFSF8

Alternate names for this Gene: CD153|CD30L|CD30LG|TNLG3A

Gene Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 9

Location in Chromosome : 9q32-q33.1

Description of this Gene: TNF superfamily member 8

Type of Gene: protein-coding

Gene: DELEC1

Alternate names for this Gene: CTS9|DEC1

Gene Summary: The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas.

Gene is located in Chromosome: 9

Location in Chromosome : 9q33.1

Description of this Gene: deleted in esophageal cancer 1

Type of Gene: ncRNA

rs3181348 in TNFSF8;DELEC1 gene and Blood basophil count (lab test) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs1322054 in TNFSF8;DELEC1 gene and Crohn Disease PMID 16221758 2005 Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease.

PMID 23266558 2013 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.

rs10982456 in TNFSF8;DELEC1 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs3181372 in TNFSF8;DELEC1 gene and Primary biliary cirrhosis PMID 23000144 2012 Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.