Gene: TNK2

Alternate names for this Gene: ACK|ACK-1|ACK1|p21cdc42Hs

Gene Summary: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Gene is located in Chromosome: 3

Location in Chromosome : 3q29

Description of this Gene: tyrosine kinase non receptor 2

Type of Gene: protein-coding