Gene: TOX3

Alternate names for this Gene: CAGF9|TNRC9

Gene Summary: The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 16

Location in Chromosome : 16q12.1

Description of this Gene: TOX high mobility group box family member 3

Type of Gene: protein-coding

rs2193094 in TOX3 gene and Breast Carcinoma PMID 25956309 2015 Genome-wide association study of susceptibility loci for breast cancer in Sardinian population.

PMID 24493630 2014 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.

rs12443621 in TOX3 gene and Malignant neoplasm of breast PMID 17529967 2007 Genome-wide association study identifies novel breast cancer susceptibility loci.