Gene: TPH2

Alternate names for this Gene: ADHD7|NTPH

Gene Summary: This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Gene is located in Chromosome: 12

Location in Chromosome : 12q21.1

Description of this Gene: tryptophan hydroxylase 2

Type of Gene: protein-coding

rs120074176 in TPH2 gene and ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7 PMID 18347598 2008 A loss-of-function mutation in tryptophan hydroxylase 2 segregating with attention-deficit/hyperactivity disorder.

rs17110563 in TPH2 gene and Serum total cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.