Gene: TRAF3IP1

Alternate names for this Gene: FAP116|IFT54|MIP-T3|MIPT3|SLSN9

Gene Summary: The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9.

Gene is located in Chromosome: 2

Location in Chromosome : 2q37.3

Description of this Gene: TRAF3 interacting protein 1

Type of Gene: protein-coding

rs77008212 in TRAF3IP1 gene and Astigmatism PMID 30306274 2018 Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci.

rs750055952 in TRAF3IP1 gene and SENIOR-LOKEN SYNDROME 9 PMID 26487268 2015 Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization.

rs3739070 in TRAF3IP1 gene and Tonometry PMID 29617998 2018 Genome-wide association analyses identify new loci influencing intraocular pressure.