Gene: TRAF3IP2-AS1

Alternate names for this Gene: C6UAS|C6orf3|NCRNA00248|TRAF3IP2-AS2

Gene Summary:

Gene is located in Chromosome: 6

Location in Chromosome : 6q21

Description of this Gene: TRAF3IP2 antisense RNA 1

Type of Gene: ncRNA

Gene: TRAF3IP2

Alternate names for this Gene: ACT1|C6orf2|C6orf4|C6orf5|C6orf6|CANDF8|CIKS|PSORS13

Gene Summary: This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.

Gene is located in Chromosome: 6

Location in Chromosome : 6q21

Description of this Gene: TRAF3 interacting protein 2

Type of Gene: protein-coding

rs33980500 in TRAF3IP2-AS1;TRAF3IP2 gene and Arthritis, Psoriatic PMID 20953186 2010 Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.

PMID 26626624 2015 Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.

rs2179070 in TRAF3IP2-AS1;TRAF3IP2 gene and Inflammatory Bowel Diseases PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

rs33980500 in TRAF3IP2-AS1;TRAF3IP2 gene and PSORIASIS 13, SUSCEPTIBILITY TO PMID 20953188 2010 Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.

PMID 20953186 2010 Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.

rs13210247 in TRAF3IP2-AS1;TRAF3IP2 gene and Psoriasis PMID 20953188 2010 Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.

PMID 23143594 2012 Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.

rs33980500 in TRAF3IP2-AS1;TRAF3IP2 gene and Psoriasis vulgaris PMID 26626624 2015 Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.