Gene: TRAK1

Alternate names for this Gene: EIEE68|MILT1|OIP106

Gene Summary:

Gene is located in Chromosome: 3

Location in Chromosome : 3p22.1

Description of this Gene: trafficking kinesin protein 1

Type of Gene: protein-coding

rs1046910 in TRAK1 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs1553608726 in TRAK1 gene and Movement Disorders PMID 28364549 2017 Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy.

PMID 18675823 2008 Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking.

PMID 23395375 2013 TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites.

PMID 28300646 2017 Developmental changes in trak-mediated mitochondrial transport in neurons.

PMID 15644324 2005 GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin.

PMID 16380713 2006 Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice.

PMID 12435728 2003 Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase.

PMID 24161670 2013 Delineation of the TRAK binding regions of the kinesin-1 motor proteins.

PMID 23603762 2013 Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.