Gene: TRHR
Alternate names for this Gene: CHNG7|TRH-R
Gene Summary: This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance.
Gene is located in Chromosome: 8
Location in Chromosome : 8q23.1
Description of this Gene: thyrotropin releasing hormone receptor
Type of Gene: protein-coding
rs16892496 in
TRHR gene and
Lean body mass
PMID 19268274 2009 Subjects carrying unfavorable genotypes at rs16892496 and rs7832552 had, on average, 2.70 and 2.55 kg lower LBM, respectively, compared to those with alternative genotypes.
PMID 19268274 2009 Subjects carrying unfavorable genotypes at rs16892496 and rs7832552 had, on average, 2.70 and 2.55 kg lower LBM, respectively, compared to those with alternative genotypes.
rs12544197 in
TRHR gene and
White Blood Cell Count procedure
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.