Gene: TRIM37

Alternate names for this Gene: MUL|POB1|TEF3

Gene Summary: This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders.

Gene is located in Chromosome: 17

Location in Chromosome : 17q22

Description of this Gene: tripartite motif containing 37

Type of Gene: protein-coding

rs74370218 in TRIM37 gene and Intelligence PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

rs121908391 in TRIM37 gene and Mulibrey Nanism PMID 10888877 2000 Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism.

PMID 21865362 2011 Testicular failure and male infertility in the monogenic Mulibrey nanism disorder.

PMID 17100991 2006 Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism.

PMID 17551331 2007 A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy.

PMID 12754710 2003 A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity.

PMID 15885686 2005 TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase.

PMID 15108285 2004 Novel mutations in the TRIM37 gene in Mulibrey Nanism.

PMID 23385855 2013 Refractory congestive heart failure following delayed pericardectomy in a 12-year-old child with Mulibrey nanism due to a novel mutation in TRIM37.

PMID 15108285 2004 The sixth mutation (c.965G>T) is the first missense mutation (p.Gly322Val) associated with Mulibrey nanism.

rs8081967 in TRIM37 gene and Myeloperoxidase Measurement PMID 23620142 2013 Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.