Gene: TRIM5

Alternate names for this Gene: RNF88|TRIM5alpha

Gene Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.4

Description of this Gene: tripartite motif containing 5

Type of Gene: protein-coding

Gene: OR52N2

Alternate names for this Gene: OR11-57

Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.4

Description of this Gene: olfactory receptor family 52 subfamily N member 2

Type of Gene: protein-coding

rs1453414 in TRIM5;OR52N2 gene and Malignant neoplasm of anterior portion of floor of mouth PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs1453414 in TRIM5;OR52N2 gene and Malignant neoplasm of floor of mouth PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs1453414 in TRIM5;OR52N2 gene and Malignant neoplasm of lateral floor of mouth PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs1453414 in TRIM5;OR52N2 gene and Malignant neoplasm of mouth PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs1453414 in TRIM5;OR52N2 gene and Malignant neoplasm of other sites within the lip and oral cavity PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs1453414 in TRIM5;OR52N2 gene and Malignant neoplasm of other specified parts of mouth PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs1453414 in TRIM5;OR52N2 gene and Pharyngeal Neoplasms PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.