Gene: TSNAX-DISC1

Alternate names for this Gene: -

Gene Summary: This gene represents naturally occurring read-through transcription between the neighboring TSNAX (translin-associated factor X) and DISC1 (disrupted in schizophrenia 1) genes on chromosome 1. Alternative splicing results in multiple transcript variants, all of which are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. These alterations in gene processing may be associated with risk for psychiatric illness, most notably, schizophrenia.

Gene is located in Chromosome: 1

Location in Chromosome : 1q42.2

Description of this Gene: TSNAX-DISC1 readthrough (NMD candidate)

Type of Gene: ncRNA

Gene: DISC1

Alternate names for this Gene: C1orf136|SCZD9

Gene Summary: This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene is located in Chromosome: 1

Location in Chromosome : 1q42.2

Description of this Gene: DISC1 scaffold protein

Type of Gene: protein-coding

rs4332347 in TSNAX-DISC1;DISC1 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs4332347 in TSNAX-DISC1;DISC1 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.