Gene: TUSC3
Alternate names for this Gene: D8S1992|M33|MRT22|MRT7|MagT2|N33|OST3A|SLC58A2
Gene Summary: This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform.
Gene is located in Chromosome: 8
Location in Chromosome : 8p22
Description of this Gene: tumor suppressor candidate 3
Type of Gene: protein-coding