Gene: TYW1B

Alternate names for this Gene: LINC00069|NCRNA00069|RSAFD2

Gene Summary: Wybutosine is a hypermodified guanosine found in phenylalanine tRNA. Wybutosine functions to stabilize codon-anticodon interactions during ribosome decoding and therefore supports the maintenance of the reading frame. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. The human genome contains two closely related genes that putatively function in wybutosine synthesis. The open reading frame of this locus is disrupted in some individuals. Thus, this locus appears to be an evolving pseudogene, but may still be functional in some members of the population.

Gene is located in Chromosome: 7

Location in Chromosome : 7q11.22-q11.23

Description of this Gene: tRNA-yW synthesizing protein 1 homolog B

Type of Gene: protein-coding

rs6460033 in TYW1B gene and Parkinson Disease PMID 17052657 2006 Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data.

rs13238203 in TYW1B gene and Triglycerides measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

PMID 20686565 2010 Biological, clinical and population relevance of 95 loci for blood lipids.

rs139453187 in TYW1B gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.