Gene: UBE2D2

Alternate names for this Gene: E2(17)KB2|PUBC1|UBC4|UBC4/5|UBCH4|UBCH5B

Gene Summary: Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene.

Gene is located in Chromosome: 5

Location in Chromosome : 5q31.2

Description of this Gene: ubiquitin conjugating enzyme E2 D2

Type of Gene: protein-coding