Gene: UBE2E1

Alternate names for this Gene: UBCH6

Gene Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene is located in Chromosome: 3

Location in Chromosome : 3p24.2

Description of this Gene: ubiquitin conjugating enzyme E2 E1

Type of Gene: protein-coding

rs28405582 in UBE2E1 gene and Acne Vulgaris PMID 24927181 2014 Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.

rs13085379 in UBE2E1 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.