Gene: UGT2B7

Alternate names for this Gene: UDPGT 2B7|UDPGT 2B9|UDPGT2B7|UDPGTH2|UDPGTh-2|UGT2B9

Gene Summary: The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 4

Location in Chromosome : 4q13.2

Description of this Gene: UDP glucuronosyltransferase family 2 member B7

Type of Gene: protein-coding

rs61361928 in UGT2B7 gene and Acute Coronary Syndrome PMID 25935875 2015 Effect of genetic variations on ticagrelor plasma levels and clinical outcomes.

rs4356975 in UGT2B7 gene and Polysomnography PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

rs6422324 in UGT2B7 gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.