Gene: UHRF2
Alternate names for this Gene: NIRF|RNF107|TDRD23|URF2
Gene Summary: This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.
Gene is located in Chromosome: 9
Location in Chromosome : 9p24.1
Description of this Gene: ubiquitin like with PHD and ring finger domains 2
Type of Gene: protein-coding