Gene: ULK4

Alternate names for this Gene: FAM7C1|REC01035

Gene Summary: This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15.

Gene is located in Chromosome: 3

Location in Chromosome : 3p22.1

Description of this Gene: unc-51 like kinase 4

Type of Gene: protein-coding

rs1716983 in ULK4 gene and Alcohol consumption PMID 29912962 2018 Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

rs1717027 in ULK4 gene and Blood Pressure PMID 23972371 2013 Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.

PMID 21909110 2011 Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

rs60257661 in ULK4 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs6763508 in ULK4 gene and Chronic Lymphocytic Leukemia PMID 28112199 2017 Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

rs9815354 in ULK4 gene and Coronary heart disease PMID 21347282 2011 Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

rs114714860 in ULK4 gene and Diastolic blood pressure PMID 27841878 2017 Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.

PMID 28498854 2017 Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

PMID 29912962 2018 Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

PMID 23972371 2013 Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.

PMID 27618452 2016 The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

PMID 27736895 2016 Variant Discovery and Fine Mapping of Genetic Loci Associated with Blood Pressure Traits in Hispanics and African Americans.

PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

PMID 27618447 2016 Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

PMID 19430479 2009 Genome-wide association study of blood pressure and hypertension.

PMID 28739976 2017 Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

rs7622665 in ULK4 gene and Diastolic blood pressure measurement PMID 29912962 2018 Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

PMID 19430479 2009 Genome-wide association study of blood pressure and hypertension.

rs6763508 in ULK4 gene and Hodgkin Disease PMID 28112199 2017 Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

rs7372217 in ULK4 gene and Hypertensive disease PMID 28498854 2017 Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

rs7627367 in ULK4 gene and Intelligence PMID 21826061 2011 Genome-wide association studies establish that human intelligence is highly heritable and polygenic.

rs73071352 in ULK4 gene and Monoclonal Gammopathy of Undetermined Significance PMID 26007630 2015 Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.

PMID 30737484 2019 Genome-wide association study of monoclonal gammopathy of unknown significance (MGUS): comparison with multiple myeloma.

rs1016669 in ULK4 gene and Multiple Myeloma PMID 22120009 2011 Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.

PMID 22120009 2011 We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)).

PMID 23955597 2013 Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.

PMID 23502783 2013 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.

PMID 27363682 2016 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.

PMID 28112199 2017 Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

PMID 26007630 2015 Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.

rs73071352 in ULK4 gene and Paraproteinemias PMID 26007630 2015 Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.

PMID 30737484 2019 Genome-wide association study of monoclonal gammopathy of unknown significance (MGUS): comparison with multiple myeloma.

rs6763508 in ULK4 gene and Small Lymphocytic Lymphoma PMID 28112199 2017 Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

rs6768542 in ULK4 gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 28498854 2017 Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

rs3774372 in ULK4 gene and Systolic blood pressure measurement PMID 21909115 2011 Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

rs116837984 in ULK4 gene and response to bronchodilator PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.