Gene: UQCC2

Alternate names for this Gene: C6orf125|C6orf126|Cbp6|M19|MC3DN7|MNF1|bA6B20.2

Gene Summary: This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.31

Description of this Gene: ubiquinol-cytochrome c reductase complex assembly factor 2

Type of Gene: protein-coding

rs3818532 in UQCC2 gene and Coronary heart disease PMID 21971053 2012 Genome-wide association study of coronary artery disease in the Japanese.

rs2281829 in UQCC2 gene and Rheumatoid Arthritis PMID 19503088 2009 REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

PMID 17804836 2007 TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.

PMID 21156761 2011 A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.