Gene: USF1

Alternate names for this Gene: FCHL|FCHL1|HYPLIP1|MLTF|MLTFI|UEF|bHLHb11

Gene Summary: This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21.

Gene is located in Chromosome: 1

Location in Chromosome : 1q23.3

Description of this Gene: upstream transcription factor 1

Type of Gene: protein-coding

rs1556260 in USF1 gene and Lymphocyte Count measurement PMID 22286170 2012 The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.

rs2516839 in USF1 gene and White Blood Cell Count procedure PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.