Gene: VCAN

Alternate names for this Gene: CSPG2|ERVR|GHAP|PG-M|WGN|WGN1

Gene Summary: This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 5

Location in Chromosome : 5q14.2-q14.3

Description of this Gene: versican

Type of Gene: protein-coding

rs115912456 in VCAN gene and Body Fat Distribution PMID 30664634 2019 Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.

rs2287926 in VCAN gene and Lean body mass PMID 28724990 2017 Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.