Gene: VEZT

Alternate names for this Gene: VEZATIN

Gene Summary: This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 12

Location in Chromosome : 12q22

Description of this Gene: vezatin, adherens junctions transmembrane protein

Type of Gene: protein-coding

rs10859856 in VEZT gene and Endometriosis PMID 23104006 2012 Genome-wide association meta-analysis identifies new endometriosis risk loci.

PMID 28537267 2017 Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.