Gene: VIM

Alternate names for this Gene: -

Gene Summary: This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients.

Gene is located in Chromosome: 10

Location in Chromosome : 10p13

Description of this Gene: vimentin

Type of Gene: protein-coding

Gene: VIM-AS1

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 10

Location in Chromosome : 10p13

Description of this Gene: VIM antisense RNA 1

Type of Gene: ncRNA

rs121917775 in VIM;VIM-AS1 gene and CATARACT 30 PMID 26694549 2016 Sporadic and Familial Congenital Cataracts: Mutational Spectrum and New Diagnoses Using Next-Generation Sequencing.

PMID 28450710 2017 Targeted Exome Sequencing of Congenital Cataracts Related Genes: Broadening the Mutation Spectrum and Genotype-Phenotype Correlations in 27 Chinese Han Families.

PMID 19126778 2009 Dominant cataract formation in association with a vimentin assembly disrupting mutation.

rs864309690 in VIM;VIM-AS1 gene and Congenital cataract PMID 26694549 2016 Sporadic and Familial Congenital Cataracts: Mutational Spectrum and New Diagnoses Using Next-Generation Sequencing.

rs3758413 in VIM;VIM-AS1 gene and Low density lipoprotein cholesterol measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs3758413 in VIM;VIM-AS1 gene and Serum total cholesterol measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.