Gene: VRK2

Alternate names for this Gene: -

Gene Summary: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity.

Gene is located in Chromosome: 2

Location in Chromosome : 2p16.1

Description of this Gene: VRK serine/threonine kinase 2

Type of Gene: protein-coding

rs6719889 in VRK2 gene and Body Height PMID 31564439 2019 Harmonizing Genetic Ancestry and Self-identified Race/Ethnicity in Genome-wide Association Studies.

rs2176546 in VRK2 gene and Child Development Disorders, Pervasive PMID 28540026 2017 Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.

rs12713370 in VRK2 gene and Major Depressive Disorder PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

PMID 27479909 2016 Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.

rs2717043 in VRK2 gene and Mood Disorders PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs2312147 in VRK2 gene and Psychotic Disorders PMID 23164818 2014 Common variant at 16p11.2 conferring risk of psychosis.

rs1051061 in VRK2 gene and Schizophrenia PMID 27922604 2017 Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population.

PMID 28991256 2017 Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia.

PMID 30285260 2019 Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

PMID 28540026 2017 Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.

PMID 21791550 2011 Common variants at VRK2 and TCF4 conferring risk of schizophrenia.

PMID 19571808 2009 Common variants conferring risk of schizophrenia.

PMID 26198764 2015 Genome-wide association study of schizophrenia in Ashkenazi Jews.

PMID 29483656 2018 Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.

rs6717480 in VRK2 gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10205421 in VRK2 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.