Gene: VTCN1

Alternate names for this Gene: B7-H4|B7H4|B7S1|B7X|B7h.5|PRO1291|VCTN1

Gene Summary: This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 1

Location in Chromosome : 1p13.1-p12

Description of this Gene: V-set domain containing T cell activation inhibitor 1

Type of Gene: protein-coding

rs12046117 in VTCN1 gene and Juvenile arthritis PMID 19116933 2009 Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis.