Gene: WASL

Alternate names for this Gene: N-WASP|NWASP|WASPB

Gene Summary: This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension.

Gene is located in Chromosome: 7

Location in Chromosome : 7q31.32

Description of this Gene: WASP like actin nucleation promoting factor

Type of Gene: protein-coding

rs9649465 in WASL gene and Migraine Disorders PMID 23793025 2013 Genome-wide meta-analysis identifies new susceptibility loci for migraine.