Gene: WBP2

Alternate names for this Gene: DFNB107|GRAMD6|WBP-2

Gene Summary: The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of estrogen receptor alpha and progesterone receptor. Defects in this gene have been associated with hearing impairment.

Gene is located in Chromosome: 17

Location in Chromosome : 17q25.1

Description of this Gene: WW domain binding protein 2

Type of Gene: protein-coding

rs3988211 in WBP2 gene and Anxiety PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs1555604549 in WBP2 gene and DEAFNESS, AUTOSOMAL RECESSIVE 107 PMID 26881968 2016 Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing.