Gene: WDFY3

Alternate names for this Gene: ALFY|BCHS|MCPH18|ZFYVE25

Gene Summary: This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy.

Gene is located in Chromosome: 4

Location in Chromosome : 4q21.23

Description of this Gene: WD repeat and FYVE domain containing 3

Type of Gene: protein-coding

rs1553924800 in WDFY3 gene and MICROCEPHALY 18, PRIMARY, AUTOSOMAL DOMINANT PMID 27008544 2016 ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size.

rs6847067 in WDFY3 gene and Malignant neoplasm of oropharynx PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs6847067 in WDFY3 gene and Malignant neoplasm of posterior wall of oropharynx PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs6847067 in WDFY3 gene and Oropharyngeal Carcinoma PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs6847067 in WDFY3 gene and Primary malignant neoplasm of lateral wall of oropharynx PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs6847067 in WDFY3 gene and malignant neoplasm of lateral wall of oropharynx PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.