Gene: WDR81

Alternate names for this Gene: CAMRQ2|HYC3|PPP1R166|SORF-2

Gene Summary: This gene encodes a multi-domain transmembrane protein which is predominantly expressed in the brain and is thought to play a role in endolysosomal trafficking. Mutations in this gene are associated with an autosomal recessive form of a syndrome exhibiting cerebellar ataxia, cognitive disability, and disequilibrium (CAMRQ2). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 17

Location in Chromosome : 17p13.3

Description of this Gene: WD repeat domain 81

Type of Gene: protein-coding

Gene: MIR22HG

Alternate names for this Gene: C17orf91

Gene Summary:

Gene is located in Chromosome: 17

Location in Chromosome : 17p13.3

Description of this Gene: MIR22 host gene

Type of Gene: ncRNA

Gene: MIR22

Alternate names for this Gene: MIRN22|hsa-mir-22|miR-22

Gene Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Gene is located in Chromosome: 17

Location in Chromosome : 17p13.3

Description of this Gene: microRNA 22

Type of Gene: ncRNA