Gene: WNT16

Alternate names for this Gene: -

Gene Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.

Gene is located in Chromosome: 7

Location in Chromosome : 7q31.31

Description of this Gene: Wnt family member 16

Type of Gene: protein-coding

rs2908004 in WNT16 gene and Bone Density PMID 24945404 2014 Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.

PMID 22792071 2012 WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.

PMID 22504420 2012 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

PMID 29304378 2018 Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

rs2536189 in WNT16 gene and Bone Mineral Density Test PMID 22792070 2012 Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

PMID 22792071 2012 WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.

PMID 22504420 2012 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

PMID 24249740 2014 Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.

rs3779381 in WNT16 gene and Ischemic cardiomyopathy PMID 30251476 2019 Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study.

rs3779381 in WNT16 gene and Rheumatoid Arthritis PMID 30251476 2019 Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study.