Gene: WNT3

Alternate names for this Gene: INT4|TETAMS

Gene Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.

Gene is located in Chromosome: 17

Location in Chromosome : 17q21.31-q21.32

Description of this Gene: Wnt family member 3

Type of Gene: protein-coding

Gene: LRRC37A2

Alternate names for this Gene: LRRC37

Gene Summary:

Gene is located in Chromosome: 17

Location in Chromosome : 17q21.31-q21.32

Description of this Gene: leucine rich repeat containing 37 member A2

Type of Gene: protein-coding

rs1563304 in WNT3;LRRC37A2 gene and Atrial Fibrillation PMID 30061737 2018 Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.

rs199498 in WNT3;LRRC37A2 gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs199505 in WNT3;LRRC37A2 gene and Corpuscular Hemoglobin Concentration Mean PMID 23222517 2012 Seventy-five genetic loci influencing the human red blood cell.

rs199525 in WNT3;LRRC37A2 gene and Forced expiratory volume function PMID 30061609 2018 Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

rs199512 in WNT3;LRRC37A2 gene and Handedness PMID 31504236 2019 In particular, with rs199512, we identified a common genetic influence on handedness, psychiatric phenotypes, Parkinson's disease, and the integrity of white matter tracts connecting the same language-related regions identified in the handedness-imaging analysis.

rs415430 in WNT3;LRRC37A2 gene and Lung Diseases, Interstitial PMID 23583980 2013 Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.

rs199505 in WNT3;LRRC37A2 gene and Major Depressive Disorder PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs199505 in WNT3;LRRC37A2 gene and Mood Disorders PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs199498 in WNT3;LRRC37A2 gene and Parkinson Disease PMID 24511991 2014 Identification of a novel Parkinson's disease locus via stratified genome-wide association study.

PMID 22451204 2012 Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.

PMID 21812969 2011 Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population.

PMID 21738487 2011 Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.

rs199505 in WNT3;LRRC37A2 gene and Primary biliary cirrhosis PMID 22961000 2012 Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

rs199525 in WNT3;LRRC37A2 gene and Vital capacity PMID 30061609 2018 Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.