Gene: WT1-AS

Alternate names for this Gene: WIT-1|WIT1|WT1-AS1|WT1AS

Gene Summary: This gene is located upstream of the Wilms tumor 1 (WT1) gene; these two genes are bi-directionally transcribed from the same promoter region. This gene is imprinted in kidney, with preferential expression from the paternal allele. Imprinting defects at chromosome 11p13 may contribute to tumorigenesis.

Gene is located in Chromosome: 11

Location in Chromosome : 11p13

Description of this Gene: WT1 antisense RNA

Type of Gene: ncRNA

Gene: WT1

Alternate names for this Gene: AWT1|GUD|NPHS4|WAGR|WIT-2|WT33

Gene Summary: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

Gene is located in Chromosome: 11

Location in Chromosome : 11p13

Description of this Gene: WT1 transcription factor

Type of Gene: protein-coding