Gene: YWHAB

Alternate names for this Gene: GW128|HEL-S-1|HS1|KCIP-1|YWHAA

Gene Summary: This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.

Gene is located in Chromosome: 20

Location in Chromosome : 20q13.12

Description of this Gene: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta

Type of Gene: protein-coding

rs2425670 in YWHAB gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2284265 in YWHAB gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs8356 in YWHAB gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.