Gene: YWHAG

Alternate names for this Gene: 14-3-3GAMMA|DEE56|EIEE56|PPP1R170

Gene Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.

Gene is located in Chromosome: 7

Location in Chromosome : 7q11.23

Description of this Gene: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma

Type of Gene: protein-coding

rs1554616627 in YWHAG gene and EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 56 PMID 28777935 2017 De Novo Mutations in YWHAG Cause Early-Onset Epilepsy.

rs2961033 in YWHAG gene and Schizophrenia PMID 30285260 2019 Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.