Gene: YY1

Alternate names for this Gene: DELTA|GADEVS|INO80S|NF-E1|UCRBP|YIN-YANG-1

Gene Summary: YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.

Gene is located in Chromosome: 14

Location in Chromosome : 14q32.2

Description of this Gene: YY1 transcription factor

Type of Gene: protein-coding

Gene: SLC25A29

Alternate names for this Gene: C14orf69|CACL|ORNT3

Gene Summary: This gene encodes a nuclear-encoded mitochondrial protein that is a member of the large family of solute carrier family 25 (SLC25) mitochondrial transporters. The members of this superfamily are involved in numerous metabolic pathways and cell functions. This gene product was previously reported to be a mitochondrial carnitine-acylcarnitine-like (CACL) translocase (PMID:128829710) or an ornithine transporter (designated ORNT3, PMID:19287344), however, a recent study characterized the main role of this protein as a mitochondrial transporter of basic amino acids, with a preference for arginine and lysine (PMID:24652292). Alternatively spliced transcript variants have been found for this gene.

Gene is located in Chromosome: 14

Location in Chromosome : 14q32.2

Description of this Gene: solute carrier family 25 member 29

Type of Gene: protein-coding

rs9291 in YY1;SLC25A29 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs9291 in YY1;SLC25A29 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.