Gene: ZFAT-AS1

Alternate names for this Gene: NCRNA00070|SAS-ZFAT|ZFAT-AS|ZFATAS

Gene Summary: This gene encodes a small antisense RNA that may be involved in regulating the sense strand locus, zinc finger and AT hook domain containing. This RNA may play a role in B cell function. A single nucleotide polymorphism in the promoter of this gene is associated with an increased risk of autoimmune thyroid disease.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.22

Description of this Gene: ZFAT antisense RNA 1

Type of Gene: ncRNA

Gene: ZFAT

Alternate names for this Gene: AITD3|ZFAT1|ZNF406

Gene Summary: This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.22

Description of this Gene: zinc finger and AT-hook domain containing

Type of Gene: protein-coding

rs1036819 in ZFAT-AS1;ZFAT gene and Pelvic Organ Prolapse PMID 22105264 2011 Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis.

rs894344 in ZFAT-AS1;ZFAT gene and Systolic Pressure PMID 28135244 2017 Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.