Gene: ZFHX3

Alternate names for this Gene: ATBF1|ATBT|C16orf47|ZFH-3|ZNF927

Gene Summary: This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 16

Location in Chromosome : 16q22.2-q22.3

Description of this Gene: zinc finger homeobox 3

Type of Gene: protein-coding

Gene: LOC102723876

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

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rs16972552 in ZFHX3;LOC102723876 gene and Smoking PMID 30643258 2019 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.