Gene: ZFYVE16

Alternate names for this Gene: PPP1R69

Gene Summary: This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants.

Gene is located in Chromosome: 5

Location in Chromosome : 5q14.1

Description of this Gene: zinc finger FYVE-type containing 16

Type of Gene: protein-coding

rs249038 in ZFYVE16 gene and Psoriasis PMID 25854761 2015 Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.