Gene: ZFYVE26

Alternate names for this Gene: FYVE-CENT|SPG15

Gene Summary: This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15.

Gene is located in Chromosome: 14

Location in Chromosome : 14q24.1

Description of this Gene: zinc finger FYVE-type containing 26

Type of Gene: protein-coding

rs12891047 in ZFYVE26 gene and AMYOTROPHIC LATERAL SCLEROSIS 1 PMID 24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

rs12891047 in ZFYVE26 gene and AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE PMID 24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

rs12891047 in ZFYVE26 gene and AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) PMID 24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

rs12891047 in ZFYVE26 gene and Amyotrophic Lateral Sclerosis, Sporadic PMID 24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

rs752283089 in ZFYVE26 gene and Movement Disorders PMID 24267886 2013 Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism.

PMID 25497598 2015 Exome sequencing in undiagnosed inherited and sporadic ataxias.

rs370828455 in ZFYVE26 gene and Spastic Paraplegia PMID 6944241 1981 [Koryak of Kamchatka. The genetic differentiation of the population].

PMID 27544497 2016 Spastizin mutation in hereditary spastic paraplegia with thin corpus callosum.

PMID 18394578 2008 Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome.

PMID 19805727 2009 SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum.

rs1555394376 in ZFYVE26 gene and Spastic Paraplegia, Hereditary PMID 28832565 2017 Massive sequencing of 70 genes reveals a myriad of missing genes or mechanisms to be uncovered in hereditary spastic paraplegias.

rs1049504575 in ZFYVE26 gene and Spastic paraplegia 15, autosomal recessive PMID 19805727 2009 SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum.

PMID 24833714 2014 Overlapping phenotypes in complex spastic paraplegias SPG11, SPG15, SPG35 and SPG48.

PMID 18394578 2008 Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome.

PMID 23733235 2013 Autosomal recessive hereditary spastic paraplegia-clinical and genetic characteristics of a well-defined cohort.

PMID 19917823 2009 Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia.

PMID 26633545 2016 Molecular diagnostic experience of whole-exome sequencing in adult patients.

PMID 27544497 2016 Spastizin mutation in hereditary spastic paraplegia with thin corpus callosum.

PMID 25497598 2015 Exome sequencing in undiagnosed inherited and sporadic ataxias.

PMID 27217339 2016 Genetic and phenotypic characterization of complex hereditary spastic paraplegia.

PMID 25525159 2015 RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease.